Start James Cook III or Ashton Jeanty? Week 6

Our Week 6 call

Start James Cook III over Ashton Jeanty in Week 6.

Market-based projections have James Cook III at 17.5 points and Ashton Jeanty at 16.3, a gap of 1.2. That is inside the noise of a single catch, so treat it as close to a coin flip. Drafters take James Cook III at ADP 2 and Ashton Jeanty at 9.

What the market projects

Player markets imply 17.5 fantasy points for James Cook III, with 100 percent of the markets a RB needs posted.

The market has James Cook III at 92.5 rushing yards, 8.5 receiving yards and 1.5 receptions, with a 62% chance to score a touchdown (7, 8, 8 and 6 market sources).

Player markets imply 16.3 fantasy points for Ashton Jeanty, with 100 percent of the markets a RB needs posted.

The market has Ashton Jeanty at 56.5 rushing yards, 24.5 receiving yards and 3.5 receptions, with a 55% chance to score a touchdown (8, 8, 6 and 5 market sources).

That puts James Cook III 1.2 points ahead of Ashton Jeanty on the market projections.

Week 6 matchups

James Cook III and BUF visit LV on Sunday at 4:25 PM ET.

LV allowed 22.3 fantasy points a game to RBs this season over 5 games, the 12th most in the league.

Running backs ran for 116 yards and 0.8 touchdowns a game against LV and caught passes for 29 more yards.

Ashton Jeanty and LV host BUF on Sunday at 4:25 PM ET.

BUF allowed 28.2 fantasy points a game to RBs this season over 5 games, the 3rd most in the league.

Running backs ran for 86 yards and a touchdown a game against BUF and caught passes for 48 more yards.

By points allowed to the position, Ashton Jeanty has the softer matchup.

Injury status

James Cook III is not on the injury report.

Ashton Jeanty is not on the injury report.

Usage before Week 6

Through Week 5, Ashton Jeanty played 72 percent of LV snaps, took 68 percent of the carries, drew 17 percent of the targets and had 47 percent of the red zone chances.

Ashton Jeanty, Week 2 against LAC: 51 of 63 snaps, 21 carries for 48 yards, 7 targets and 4 catches for 15 yards.

Ashton Jeanty, Week 3 against NO: 59 of 70 snaps, 19 carries for 56 yards, 3 targets and 3 catches for 37 yards.

Ashton Jeanty, Week 4 against KC: 56 of 84 snaps, 15 carries for 58 yards, 8 targets and 6 catches for 68 yards.

Ashton Jeanty, Week 5 against NE: 32 of 60 snaps, 10 carries for 27 yards, 6 targets and 3 catches for 50 yards.

Their 2025 seasons

In 2025, James Cook III played 17 games for BUF and scored 302.2 PPR points, 17.8 a game, finishing RB6.

He ran 309 times for 1621 yards and 12 touchdowns, and caught 33 of 40 targets for 291 yards.

He was on the field for 60 percent of the offense's snaps in the games he played.

James Cook III, Week 18 of 2025 against NYJ: 2 carries for 15 yards, 0 targets and 0 catches for 0 yards, 1.5 PPR points.

James Cook III, Week 17 of 2025 against PHI: 39 of 76 snaps, 20 carries for 74 yards, 4 targets and 1 catch for 3 yards, 8.7 PPR points.

James Cook III, Week 16 of 2025 against CLE: 28 of 50 snaps, 16 carries for 117 yards, 2 targets and 1 catch for 17 yards, 2 touchdowns, 26.4 PPR points.

In 2025, Ashton Jeanty played 17 games for LV and scored 245.1 PPR points, 14.4 a game, finishing RB11.

He ran 266 times for 975 yards and 5 touchdowns, and caught 55 of 73 targets for 346 yards.

He was on the field for 76 percent of the offense's snaps in the games he played.

Their other Week 6 calls

• Start James Cook III over Bhayshul Tuten.
• Start Bijan Robinson over James Cook III.
• Start James Cook III over Cam Skattebo.
• Start Bhayshul Tuten over Ashton Jeanty.
• Start Bijan Robinson over Ashton Jeanty.
• Start Ashton Jeanty over Blake Corum.