Start James Cook III or Chase Brown? Week 6

Our Week 6 call

Start James Cook III over Chase Brown in Week 6.

James Cook III is projected from market data at 17.5 points. Chase Brown has no player market posted for this week, so his side of this call rests on consensus ADP and his injury status only. Drafters take James Cook III at ADP 2 and Chase Brown at 5.

What the market projects

No player market was posted for Chase Brown in Week 6.

Player markets imply 17.5 fantasy points for James Cook III, with 100 percent of the markets a RB needs posted.

The market has James Cook III at 92.5 rushing yards, 8.5 receiving yards and 1.5 receptions, with a 62% chance to score a touchdown (7, 6, 7 and 5 market sources).

Week 6 matchups

James Cook III and BUF visit LV on Sunday at 4:25 PM ET.

LV allowed 22.3 fantasy points a game to RBs this season over 5 games, the 12th most in the league.

Running backs ran for 116 yards and 0.8 touchdowns a game against LV and caught passes for 29 more yards.

Injury status

Chase Brown is not on the injury report.

James Cook III is not on the injury report.

Usage before Week 6

Through Week 5, Chase Brown played 70 percent of CIN snaps, took 65 percent of the carries, drew 15 percent of the targets and had 29 percent of the red zone chances.

Chase Brown, Week 2 against HOU: 42 of 60 snaps, 20 carries for 80 yards, 5 targets and 3 catches for 2 yards.

Chase Brown, Week 3 against PIT: 40 of 57 snaps, 13 carries for 61 yards, 2 targets and 2 catches for 8 yards.

Chase Brown, Week 4 against JAX: 60 of 76 snaps, 9 carries for 10 yards, 11 targets and 11 catches for 71 yards.

Chase Brown, Week 5 against MIA: 39 of 65 snaps, 13 carries for 39 yards, 4 targets and 3 catches for 21 yards.

Their 2025 seasons

In 2025, Chase Brown played 17 games for CIN and scored 282.6 PPR points, 16.6 a game, finishing RB7.

He ran 232 times for 1019 yards and 6 touchdowns, and caught 69 of 88 targets for 437 yards.

He was on the field for 67 percent of the offense's snaps in the games he played.

In 2025, James Cook III played 17 games for BUF and scored 302.2 PPR points, 17.8 a game, finishing RB6.

He ran 309 times for 1621 yards and 12 touchdowns, and caught 33 of 40 targets for 291 yards.

He was on the field for 60 percent of the offense's snaps in the games he played.

James Cook III, Week 18 of 2025 against NYJ: 2 carries for 15 yards, 0 targets and 0 catches for 0 yards, 1.5 PPR points.

James Cook III, Week 17 of 2025 against PHI: 39 of 76 snaps, 20 carries for 74 yards, 4 targets and 1 catch for 3 yards, 8.7 PPR points.

James Cook III, Week 16 of 2025 against CLE: 28 of 50 snaps, 16 carries for 117 yards, 2 targets and 1 catch for 17 yards, 2 touchdowns, 26.4 PPR points.

Their other Week 6 calls

• Start Chase Brown over Ashton Jeanty.
• Start Chase Brown over Chris Rodriguez Jr..
• Start Chase Brown over D'Andre Swift.
• Start James Cook III over Ashton Jeanty.
• Start James Cook III over Bhayshul Tuten.
• Start Bijan Robinson over James Cook III.