Start James Cook III or Jaylen Warren? Week 6

Our Week 6 call

Start Jaylen Warren over James Cook III in Week 6.

Market-based projections have Jaylen Warren at 17.9 points and James Cook III at 17.0, a gap of 0.9. That is inside the noise of a single catch, so treat it as close to a coin flip. No player market is posted for Jaylen Warren this week yet, so his 17.9 is the average of his market-based projections in Weeks 3, 4 and 5 (15.9, 19.9 and 17.8); the call is rebuilt when his market posts.

What the market projects

No Week 6 player market is posted for Jaylen Warren yet. His market-based projections were 15.9, 19.9 and 17.8 points in Weeks 3, 4 and 5, an average of 17.9, which stands in until his Week 6 market posts.

The market gives Jaylen Warren a 49% chance to score a touchdown (13 market sources).

Player markets imply 17.0 fantasy points for James Cook III, with 100 percent of the markets a RB needs posted.

The market-based projection for James Cook III is 93 rushing yards, 8 receiving yards and 1-2 receptions, with a 59% chance to score a touchdown (10, 10, 12 and 13 market sources).

That puts Jaylen Warren 0.9 points ahead of James Cook III on these projections.

Week 6 matchups

James Cook III and BUF visit LV on Sunday at 4:25 PM ET.

LV allowed 22.3 fantasy points a game to RBs this season over 5 games, the 12th most in the league.

Running backs ran for 116 yards and 0.8 touchdowns a game against LV and caught passes for 29 more yards.

Injury status

Jaylen Warren is not on the injury report.

James Cook III is not on the injury report.

Usage before Week 6

Through Week 5, Jaylen Warren played 76 percent of PIT snaps, took 69 percent of the carries, drew 15 percent of the targets and had 25 percent of the red zone chances.

Jaylen Warren, Week 2 against NE: 50 of 70 snaps, 11 carries for 43 yards, 4 targets and 2 catches for 34 yards.

Jaylen Warren, Week 3 against CIN: 56 of 62 snaps, 17 carries for 127 yards, 4 targets and 3 catches for 49 yards.

Jaylen Warren, Week 4 against CLE: 70 of 72 snaps, 17 carries for 93 yards, 6 targets and 3 catches for 33 yards.

Jaylen Warren, Week 5 against IND: 52 of 60 snaps, 15 carries for 101 yards, 6 targets and 6 catches for 87 yards, 2 touchdowns.

Their 2025 seasons

In 2025, Jaylen Warren played 16 games for PIT and scored 217.1 PPR points, 13.6 a game, finishing RB17.

He ran 211 times for 958 yards and 6 touchdowns, and caught 40 of 45 targets for 333 yards.

He was on the field for 51 percent of the offense's snaps in the games he played.

In 2025, James Cook III played 17 games for BUF and scored 302.2 PPR points, 17.8 a game, finishing RB6.

He ran 309 times for 1621 yards and 12 touchdowns, and caught 33 of 40 targets for 291 yards.

He was on the field for 60 percent of the offense's snaps in the games he played.

James Cook III, Week 18 of 2025 against NYJ: 2 carries for 15 yards, 0 targets and 0 catches for 0 yards, 1.5 PPR points.

James Cook III, Week 17 of 2025 against PHI: 39 of 76 snaps, 20 carries for 74 yards, 4 targets and 1 catch for 3 yards, 8.7 PPR points.

James Cook III, Week 16 of 2025 against CLE: 28 of 50 snaps, 16 carries for 117 yards, 2 targets and 1 catch for 17 yards, 2 touchdowns, 26.4 PPR points.

Their other Week 6 calls

• Start Jaylen Warren over Ashton Jeanty.
• Start Bijan Robinson over Jaylen Warren.
• Start Jaylen Warren over Bucky Irving.
• Start James Cook III over Ashton Jeanty.
• Start James Cook III over Bhayshul Tuten.
• Start Bijan Robinson over James Cook III.